Launch of the project and the first volunteers in the study of a vaccine against deadly viruses in 1 week.

ACCELLENA has launched phase 1 clinical trials of a combined vector vaccine for the prevention of infectious diseases caused by Ebola viruses Zaire, Bundibugyo, Sudan and Marburg virus. The first volunteers were included in the study 1 week after signing the contract with the vaccine developer.

The contract from the sponsor was received on 11/22/22, the next day an agreement was concluded with the center and a qualifying visit was held on 11/24, on 11/25 the center was opened. On December 1, the laying of the 1st group of volunteers and the introduction of the vaccine were carried out. Thus, the CT started as soon as possible, despite the fact that one of the tasks within the CT is the delivery of warm blood samples from the research center in St. Petersburg to the central laboratory in Moscow in a short 5 hours.

The universal human importance that all participants of the project are facing is obvious: the Ebola virus causes an acute severe illness that is often fatal if left untreated. EVD first emerged in 1976 with two simultaneous outbreaks in Nzara (now South Sudan) and Yambuku, DRC. The second outbreak occurred in a village near the Ebola River, from which the disease takes its name.

Outbreak in West Africa 2014-2016 is the largest and most complex Ebola outbreak since the discovery of the virus in 1976. More people fell ill and died in this outbreak than in all other outbreaks combined. It also spreads between countries, starting in Guinea and spreading across land borders to Sierra Leone and Liberia. Current outbreak 2018–2019 in the eastern regions of the DRC is extremely complex, also because the public health response is seriously hampered by insecurity. At the moment, it has been shown that the study vaccine is quite safe to use, does not cause SAEs and severe post-vaccination effects.

The Filoviridae family of viruses includes 3 genera: Lloviu, Marburg and Ebola. 6 types of Ebola have been identified: Zaire, Bundibugyo, Sudan, Reston and Tai forest and Bombali. The virus that caused the current outbreak in the DRC and the 2014–2016 outbreaks in West Africa, refers to the species Zaire ebolavirus. The first three Ebola viruses Bundibugyo, Zaire and Sudan have been associated with major outbreaks in Africa. The largest outbreak occurred in Angola, with a mortality rate of 88%.

In the summer of 2022, the Ghanaian health service confirmed two cases of Marburg fever, a dangerous disease with a high lethality. Its pathogen belongs to the same family as the Ebola virus. There is currently no vaccine or cure for this virus. News source: